Two-Day Symposium for Molecular Biologists involved in Molecular Pathology Diagnostics and Research


The Two-Day Symposium for Molecular Biologists involved in Molecular Pathology Diagnostics and Research will again broaden the spectrum of the European Congress of Pathology. The symposium will take place on Monday, 10 September 2018 and Tuesday, 11 September 2018.

Our increasing knowledge of the molecular basis of disease opens the doors to new therapy options for cancer patients. The use of molecular data nowadays directly impacts patient treatment. The major goals for scientists working together with pathologists and clinicians in the field are to provide high-quality molecular diagnostics but at the same time to translate basic research discoveries into clinical practice.

In this workshop current advances but also challenges and problem-solving approaches in the field of molecular pathology will be addressed and discussed. The symposium will focus primarily on the interests of molecular biologists working in pathology molecular diagnostics and research. 

Preliminary Programme

Monday, 10 September 2018

Room E

08:30 - 15:45

MB-01 | Immunotherapy biomarkers

Chairs: 
Marjolijn Ligtenberg, The Netherlands
Sabine Merkelbach-Bruse, Germany

001 08:30 - 09:30
Update in immuno-oncology - a clinician's view
David Heigener, Germany


09:30 - 10:30 Coffee Break


002
10:30 - 11:00
Multiparametric biomarkers for immunotherapy: the lung cancer paradigm
Fernando Lopez-Rios, Spain

003 11:00 - 11:30
Evaluation and harmonisation of biomarkers for checkpoint therapy in France
Etienne Rouleau, France

004 11:30 - 12:00
The German TMB consortium: comparing and harmonising mutational load assays
Albrecht Stenzinger, Germany

12:15 - 13:00 Keynote Lecture
13:00 - 14:30 Lunch Break

005 14:45 - 15:15
ctDNA as a biomarker for early tumour response assessment in lung cancer patients treated with immunotherapy
Ed Schuuring, The Netherlands

006 15:15 - 15:45
Multisprectral imaging for immune infiltrates
Patrick Micke, Sweden

15:45 - 16:45

MB-02 | Selected abstracts from the Working Group Molecular Pathology

Chairs:
Cristina Teixido, Spain
Carina Heydt, Germany

001 15:45 - 15:55
Comparison of DNA- and RNA-based parallel sequencing approaches for the detection of MET Exon 14 skipping mutations
Carina Heydt, Germany

002 15:55 - 16:05
Tumour mutational load, a better predictive marker for inmunoresponse than PDL1 in clinical practice?
Javier Freire, Spain

003 16:05 - 16:15
A rapid library preparation method with custom assay designs for detection of variants at 0.1% allelic frequency in liquid biopsy samples
Cristina Van Loy, USA

004 16:15 - 16:25
Tumour mutation burden assessment from FFPE research samples using a targeted next-generation sequencing assay
Ruchi Chaudhary, USA

005 16:25 - 16:35
The future of cancer classification: evidence-informed pathology
Ian Cree, France

006 16:35 - 16:45
Toward the automated scoring of fluorescence in situ hybridisation using a confocal whole slide image scanner
Yukako Yagi, USA

17:15 - 19:15

MB-03 | Liquid biopsies

Chairs:
Cristina Teixido, Spain
Carina Heydt, Germany

001 17:15 - 17:45
Pros and cons of liquid biopsy: ready to replace tissue?
Federico Rojo, Spain

002 17:45 - 18:15
Novel technologies: how to approach liquid biopsies testing
Atocha Romero, Spain

003 18:15 - 18:45
Alternative forms of liquid biopsy: beyond ctDNA
Clara Mayo, Spain

004 18:45 - 19:15
Quality assurance in liquid biopsy testing: results from German EQA schemes
Sabine Merkelbach-Bruse, Germany

Tuesday, 11 September 2018

Room E

08:30 - 11:00

MB-04| Bioinformatics

Chairs: 
Frederick Klauschen, Germany
Bastiaan Tops, The Netherlands

001 08:30 - 09:00
Next-generation-sequencing bioinformatics pipeline. From algorithms to data bases
Dieter Beule, Germany

002 09:00 - 09:30
Bioinformatic approaches for the integration of genomic profiling with proteomics and imaging data
Frederick Klauschen, Germany

09:30 - 10:30 Coffee Break

003 10:30 - 11:00
A Mutect2 based tumour mutational burden pipeline for whole exome and gene panel data
Jan Rehker, Germany

11:00 - 15:45

MB-05 | Next Generation Sequencing

Chairs: 
Winand Dinjens, The Netherlands
Sabine Merkelbach-Bruse, Germany

001 11:00 - 12:00 | Dual presentation
Brain tumours: a revolution of diagnostics
Martin J. van den Bent, The Netherlands
Hendrikus J. Dubbink, The Netherlands

12:15 - 13:00 Keynote Lecture
13:00 - 14:30 Lunch Break

002 14:45 - 15:15
Stand up and be counted – molecular barcoding for the masses
Karl Kashofer, Austria

003 15:15 - 15:45
Benchmarking your NGS service: results from 3 years of EQA and looking to the next 3 years
Sandi Deans, United Kingdom

15:45 - 17:45

MB-06 | Borders of somatic and germline testing

Chairs: 
Marjolijn Ligtenberg, The Netherlands
Bastiaan Tops, The Netherlands

001 15:45 - 16:15
Detection of tumour and germline alterations – experience from molecular diagnostic studies in personalised paediatric oncology
Kristian Pajtler, Germany

002 16:15 - 16:45
Somatic mutational footprints of cancer predisposition
Roland KuiperThe Netherlands

003 17:15 - 17:45
Extended BRCAness testing in ovarian and breast cancer for therapy response prediction
Petra NederlofThe Netherlands

17:45 - 19:15

MB-07 | Novel technological developments

Chairs: 
Winand Dinjens, The Netherlands
Frederick Klauschen, Germany

001 17:45 - 18:15
Powering precision oncology research: developing gene expression signatures and high plex digital spatial profiling technology
Rudy van Eijsden, The Netherlands

002 18:15 - 18:45
Automated 3D cellular profiling of intact tumours
Ravian van IneveldThe Netherlands

003 18:45 - 19:15
Deciphering the human methylome in health and disease
Joost GribnauThe Netherlands

Registration and payment received after 3 July 2018
Two-Day Symposium Molecular Biologists* EUR 200
   
* For participants with a full ECP registration, the Two-Day Symposium for Molecular Biologists is included in the registration fee.


Organisers of the Symposium:


  • Sabine Merkelbach-Bruse, Germany
  • Marjolijn Ligtenberg, The Netherlands
  • Cristina Teixido, Spain
  • Frederick Klauschen, Germany
  • Bastiaan Tops, The Netherlands
  • Winand Dinjens, The Netherlands